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Copper Amino Isolate Lipid 1%
(CAIL 1%) Core Regimen - Size: 15ml 104.00 USD
  • ph 5.00-6.00
  • alcohol-free
  • oil-free
  • silicone-free
  • nut-free
  • vegan
  • gluten-free
  • cruelty-free


Copper Amino Isolate Lipid (CAIL) 1% is the latest addition to NIOD’s core regimen collection. Designed for PM use, the formula has a blue gel-like texture that melts into a comfortable oil-like feel upon application. An enhanced approach to targeting overall healthy-looking skin, this pro-collagen, pro-lipid, pro-fat formula branches from the concept of NIOD’s multi-award-winning Copper Amino Isolate Serum, with the additional benefits of building and enhancing skin barrier function, elasticity and integrity via lipophilic pathways. In general, healthy-looking skin maintains a careful balance of glycosaminoglycans (GAGs), extracellular proteins such as collagen and elastin, and epidermal surface lipids, corneocytes, adipocytes, and sebocytes. CAIL 1% is designed with a highly focused effort to target all of the aforementioned skin components, improving volume and resilience by elevating the skin to optimal conditions.


Tripeptide-1 (Palmitoyl) Copper
The formula incorporates a solubilised format of pure Palmitoyl-GHK-Cu at a 1% concentration by weight. Palmitoyl-GHK-Cu is a version of GHK-Cu with a Palmitoyl group attached to its structure to enhance its lipophilic properties for improved skin affinity. This peptide works synergistically to restore and maintain a youthful appearance of the skin.

GHK-Cu is found in nature and is originally isolated from human plasma. The natural role of this peptide, as found in the human body, includes the activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses.

Zizanoic Vetiver
A unique upcycled ingredient, derived from the roots of vetiver exhausted by the fragrance industry, Zizanoic Vetiver has properties to support skin tonicity, volume and firmness.

Over time, reduced adipocyte integrity and a decrease in the volume of facial fat affects the mechanical stability of the skin and leads to aging. The appearance of aging can also be attributed to reduced sebum production, decreased keratinisation, and a reduction in the adipocytes capacity to store fat. Zizanoic Vetiver promotes the improved appearance of skin volume redefinition and firmness while promoting an overall plumping effect.

Patented Dihydrodiisoeugenol Complex
With aging, the distribution of fat tissue changes due to the inhibition of adipogenesis and increased fat degradation via stimulated lipolysis.

Patented Dihydrodiisoeugenol Complex is a novel, multi-faceted approach to enhancing skin resilience using a dual mode of action to approach the decline in subcutaneous fat.

This unique complex aims to counteract the appearance of a decrease in adipose tissue by improving the elasticity and firmness of the skin, particularly when applied to the cheeks and jawline.

Aphanizomenon Aquaflo
A newly-discovered blue-green algae that is rich in vitamins, amino acids, and minerals to promote the replenishment of the superficial protective barrier of the stratum corneum.

Aphanizomenon Aquaflo functions to smoothen the skin surface for a younger appearance by facilitating the skin’s natural moisturizing factors. Prominent in Proline and Lysine, Aphanizomenon Aquaflo improves skin elasticity and reduces the appearance of wrinkles.

Plant-derived Squalane
A vegetable hydrocarbon renowned for its emollience and capacity to maintain skin’s moisture barrier, squalane is an excellent hydrator that can replenish hydration, imparting suppleness and flexibility to the skin.


CAIL1% is designed to be used on its own after cleansing. Apply a very small amount to face and neck in the evening. If incorporated into the NIOD core regimen, Multi-Molecular Hyaluronic Complex (MMHC) may be used after the application of this product. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised. Refer to our in-depth guide to patch testing. Keep out of reach of children.


Squalane, Caprylic/Capric Triglyceride, Aqua (Water), Glycerin, Hydrogenated Starch Hydrolysate, Glycolipids, Sucrose Laurate, Propanediol, Tripeptide-1 (Palmitoyl) Copper, Hydroxymethoxyphenyl Propylmethylmethoxybenzofuran, Vetiveria Zizanoides Root Extract, Aphanizomenon Flos-aquae Extract, Sucrose Stearate, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol.

Our formulations are updated from time to time as part of our commitment to innovation. As such, the ingredient list shown here may vary from the box of the product depending on time and region of purchase.